Symbol
Name
ID

Map3k12
mitogen-activated protein kinase kinase kinase 12
MGI:1346881

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

nervous system phenotype

decreased neuron apoptosis

abnormal neuron differentiation

abnormal axon extension

abnormal neuronal migration

slow Wallerian degeneration

abnormal brain morphology

abnormal brain white matter morphology

decreased corpus callosum size

abnormal anterior commissure morphology

abnormal anterior commissure pars anterior morphology

abnormal anterior commissure pars posterior morphology

absent anterior commissure

abnormal brain internal capsule morphology

abnormal cingulum morphology

abnormal cerebral cortex morphology

abnormal olfactory bulb morphology

abnormal olfactory tract morphology

increased motor neuron number

decreased retina ganglion cell number

abnormal dorsal root ganglion morphology

Availability

Mouse Genotype

Map3k12^{Gt(RRN366)Byg}/Map3k12^{Gt(RRN366)Byg}

Map3k12^tm1.1Lewc/Map3k12^tm1.1Lewc

Map3k12^tm1.1Lewc/Map3k12^tm1.1Lewc
Tg(Mnx1-GFP)1Slp/0

Map3k12^tm1.2Adia/Map3k12^tm1.2Adia

Map3k12^tm1Shir/Map3k12^tm1Shir

Map3k12^tm1.1Adia/Map3k12^tm1.1Adia (conditional)

Map3k12^tm1Lbh/Map3k12^tm1Lbh (conditional)

Map3k12^tm1Lewc/Map3k12^tm1Lewc
Tg(CAG-cre/Esr1*)5Amc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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